FASEP
Fabry and Stroke Epidemiological Protocol
Risk factors in ischemic stroke patients with Fabry disease -
An international, multicenter, epidemiological protocol
| Estimated enrollment: | 1000 |
| Study start date: | August 2010 |
| Study completion date: |
December 2012 |
| Study overview The purpose of this study is to determine in a large number of young stroke patients, how many strokes were caused by Fabry disease and what risk factors might be able to predict this disease. More than one million people in Europe suffer from a stroke every day. Normally older people have a stroke, but also a significant number of younger people between 18 and 55 years. Usually, these can only be explained for a minority by the classical risk factors such as diabetes, overweight and high blood pressure. New studies indicate that in about 1 - 2 % of the younger stroke patients the etiology can be an undiagnosed genetic disease, e.g. Fabry disease. Fabry disease is a lysosomal storage disorder known to cause vasculopathy. Fabry diagnostic will be done centrally: blood samples will be stored for analysis of a-galactosidase in blood, Gb3 as well as lyso-Gb3. In all cases direct analysis of the gene willl be done, especially in females where due to the Lyonisation effect a-galactosidase activity might be normal in blood although the patient might suffer from Fabry disease. |
| Study contact Susanne Zielke (CRA)  Fon: +49 381 494 47 39 Fax: +49 381 494 47 48 |
| This study is officially registered under NCT01182818 on clinicaltrials.gov providing additional study information. |