Project overview

In sifap ca 50 international neurological centres are joining a multicenter study headed by the Albrecht-Kossel-Institute at the University of Rostock. The goal of sifap is to clarify the prevalence of Fabry disease in young stroke patients, and to characterize stroke rehabilitation in young patients with Fabry disease.

The main study phase sifap1 examines the prevalence of underlying Fabry disease in an unselected group of about 5,000 young stroke patients. Patients can decide whether their blood should be further analyzed with respect to stroke and Fabry. Consequently, one of the biggest and best defined BioBanks (containing DNA, clinical data, MRI data) will be established. This will enable scientists to conduct further studies on the cause of stroke with information from a well defined sample pool.

In subsequent sifap2 the relapse rate of acute cerebrovascular events with clinical relevance in patients with different prophylactic therapeutic approaches will be determined. Patients with a proven Fabry disease will be included in sifap2 for a minimum follow-up of 36 months.

To unravel the prevalence of Fabry disease in young stroke patients and to realize the probably biggest study on stroke in the young and its causes, sifap 1 and 2 have been initiated.